San Francisco 49ers wide receiver Brandon Aiyuk will be the first guest to appear on his teammates' show Cleats and Convos with Deebo Samuel.

Already without Christian McCaffrey, who’s on injured reserve, the 49es also won’t have Deebo Samuel for Sunday’s game against the Rams. It was announced on Monday that Samuel has a calf strain and will miss a couple of weeks.

When Christian McCaffrey went down, the 49ers could take solace in the fact that they had another versatile and dynamic weapon in Deebo Samuel. For the next two games, the 49ers will be without both as Samuel reported to work with a calf strain that coach Kyle Shanahan said would likely keep him out two weeks.

Two former 49ers players had strong words for San Francisco's defense after Sunday's 23-17 loss to the Vikings. Ex-cornerback Richard Sherman (a Niner from 2018-2020) and ex-safety Donte Whitner (2011-2013) each criticized the defensive performance that resulted in the Week 2 defeat.

The San Francisco 49ers (1-1) and LA Rams (0-2) will renew their rivalry Sunday in an NFC West matchup. Kickoff from SoFi Stadium in Inglewood, Calif., is set for 4:25 p.m. ET (FOX). Below, we look at 49ers vs.

The Minnesota Vikings were not expected to achieve much against the 49ers on Sunday, that didn't matter to them as they mad