Ohio Democrat Sherrod Brown is projected to lose to Republican entrepreneur Bernie Moreno in Ohio, a huge blow to Senate Democrats hoping to keep control of the upper chamber.

After enduring nearly half a billion dollars’ worth of mostly negative ads for months, Ohio voters are set to decide one of the nation's most-watched Senate races.

Fox News Decision Desk has projected a winner in the Ohio Senate race, which has been one of the most closely watched in the country as Republicans try to retake Senate control.