Ohio Democrat Sherrod Brown is projected to lose to Republican entrepreneur Bernie Moreno in Ohio, a huge blow to Senate Democrats hoping to keep control of the upper chamber.

With the victory of Bernie Moreno, a wealthy former car dealer and political novice, Republicans had enough seats to win the Senate majority unless Democrats scored an upset.

Republican Bernie Moreno will defeat Democratic Sen. Sherrod Brown, CNN projects, a key pickup for the GOP in a state that’s been trending its way and putting the GOP one step closer to security the Senate majority. The three-term incumbent was already ...