The San Francisco 49ers may again be without starting quarterback Brock Purdy for their Week 13 clash with the San Francisco ...

Josh Allen, Brock Purdy and George Kittle headline the players to watch as the struggling San Francisco 49ers face the ...

The Buffalo Bills' home-field advantage will once again be on display on Sunday night with severe weather projected to be on ...

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

T he San Francisco 49ers now have an uphill battle ahead of them to reach the postseason. Winning out feels like the only way ...

The first-place Buffalo Bills are on a six-game winning streak and getting healthier. The last-place San Francisco 49ers have ...

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

Sean McDermott took over as head coach in Buffalo in 2017. Since then, the Bills have done very well in games following an ...

The Bills will take on the San Francisco 49ers on Sunday night at Highmark Stadium in Orchard Park. Lake-effect snow bands ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...