Both teams are preparing for their first conference matchup of 2024, with the Wolfpack winning two of the last three meetings since 2021, including a 24-17 victory last year. However, oddsmakers favor Clemson, and USA TODAY Sports’ six-member panel unanimously predicted a Tiger win.

SportsLine's model just revealed its college football picks for the North Carolina State Wolfpack vs. Clemson Tigers on Saturday

Here are the All Clemson staff predictions as the Clemson Tigers prepare to host their ACC home opener against the NC State Wolfpack.

Clemson DT DeMonte Capehart: Clocked at running over 17 mph in the App State game, Capehart is having the breakout year many expected of him in his fifth season. He’s the team’s best defensive tackle and has six tackles so far.

No. 21 Clemson and N.C. State have plenty in common this season. Both figured to contend in the Atlantic Coast Conference when the season began before early season nonconference losses.

How to watch the Clemson Tigers vs. NC State Wolfpack Sept. 21 college football game with tickets, start time, TV channel and live streaming information.

Clemson (1-1) was picked to finish second in the ACC race and N.C. State (2-1) was picked fourth, making this a key early matchup in the league title chase in the ACC opener for both teams. N.C. State hasn't won at Clemson since 2002 with Philip Rivers at quarterback,

As NC State travels down to the southern part of the Carolinas, they prepare to take on a Clemson team that lives somewhere between two extreme performances. In the opener with Georgia, the Tigers displayed a talented but thin defense and an absent offense.

Preview the Clemson Tigers vs. North Carolina State Wolfpack college football matchup, with score predictions, stats, and game information.