The lower hinge of immunoglobulin G (IgG), an overlooked part of the antibody, acts as a structural and functional control ...

Researchers have found that the flexibility of the structure between the arms of an antibody—the so-called “hinge”—influences the strength of the immune response that it elicits. This finding could be ...

Researchers have determined the mechanism underlying antibody hinge conformational changes, which could contribute to the development of more effective cancer treatments. A research team from the ...

Nearly half of patients with Crohn's disease (CD) develop selective serum immunoglobulin G (IgG) response to flagellin proteins expressed by bacteria in the Lachnospiraceae family. This reactivity is ...