The cytochrome P450 enzymes constitute a diverse superfamily of haem-containing proteins that catalyse key oxidative reactions in steroid biosynthesis. In the steroidogenic pathway, these enzymes ...
The cytochrome P450 enzymes form a vast superfamily of haem‐containing monooxygenases that catalyse the metabolism of a broad spectrum of endogenous substances and xenobiotics. Their dynamic catalytic ...
Cytochrome P450 Defects Linked to Opioid Regimen Efficacy Most patients with multiple defects of the cytochrome P450 system naturally gravitated toward an opioid regimen primarily metabolized through ...
It is remarkable that cancer chemotherapies, with generally narrow therapeutic windows and possibilities for life-threatening toxicities, are usually dosed according to body-surface area (BSA). The ...
As you know, the liver does much more than cope with the alcoholic aftermath of the Friday afternoon happy hour at your lab. The members of the cytochrome P450 superfamily of enzymes, the “worker bees ...
Background: Clopidogrel is a prodrug requiring metabolism by cytochrome P450 3A (CYP3A) isoenzymes, including CYP3A5, in order to be active. It is controversial whether clopidogrel interacts with ...
Phase I study of docetaxel and temsirolimus in refractory solid tumors. Background: Interactions of cytochrome P450 (CYP), especially CYP3A4, between chemotherapy agents and other xenobiotics can ...
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