THE pathogenesis of endotoxin fever has been much elucidated since the observation of the appearance in the serum of a fever-producing substance (endogenous pyrogen) after endotoxin 1. The transient ...
Recently, pyrogen has been shown to be released from normal human blood leukocytes after stimulation by endotoxin or by phagocytosis of heat-killed bacteria. 4 When injected intravenously in rabbits, ...
THE mechanism whereby bacterial infections induce fever has been elucidated in some detail 1,2. Bacteria and bacterial pyrogens (exogenous pyrogen) interact with polymorphonuclear granulocytes of the ...
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