Zon envisions using these approaches to treat clonal hematopoiesis. In this precancerous condition, which becomes more common ...

A recent study in zebrafish presents a potentially important new system for studying the process of stem cell biology and hematopoiesis, the process by which blood is produced. The zebrafish has ...

Skeletal stem cells have been isolated from various tissues, including periosteum and bone marrow, where they exhibit key functions in bone biology and hematopoiesis, respectively. The role of ...

Researchers led by Osaka University in Japan have conducted the first human trial using induced pluripotent stem-cell-derived ...

This subjects the donor cells to a fair amount of replicative stress. Some scientists are concerned that this stress could lead to clonal hematopoiesis, a phenomenon where the donated stem cells ...

A research team reported recently that heart muscle cells grown from induced pluripotent stem cells can integrate into the hearts of monkeys with a state of pressure overload.

While responses to inflammation may be necessary to maintain normal and emergency hematopoiesis, it may be deleterious over the long term, with prolonged inflammation leading to stem cell exhaustion ...

In particular, the lab is investigating the role of DNA methyltransferase 3a (DNMT3A) in regulating stem cell function, and how mutations in DNMT3A lead to age-related clonal hematopoiesis and ...

Single-cell analysis of CML patients bone marrow at diagnosis reveals coexistence of CD26-CD35+ healthy stem cells and CD26+CD35- CML stem cells, and how the ratio between these impacts TKI response.

enabling answers to long standing questions in stem cell research with a focus on hematopoiesis, pluripotent stem cells and their differentiation and bone biology. His work combines cell and molecular ...