The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) cascade is a signal transduction pathway that was originally identified in the vertebrate system 1, 2 and has been ...

The JAK2 gene is a protein-coding gene of the Janus kinase family. It plays a role in cellular signaling. Evidence notes connections between this gene and some medical conditions. Variations in this ...

Cosmetic outcome after intraoperative radiotherapy or external beam radiotherapy for early breast cancer: An objective assessment of patients from a randomized controlled trial. Effect of adjuvant ...

Ischemic stroke is a major cause of death and disability, caused by a sudden loss of oxygen supply to the brain due to blocked blood vessels. Recanalization treatments such as intravenous thrombolysis ...

New research indicates that drugs that target a cell growth pathway known as the JAK-STAT pathway are likely to be effective against certain chronic leukemias. Researchers recently discovered that a ...

Jonathan Silverberg, MD, PhD, MPH, associate professor of dermatology, director of clinical research and patch testing, George Washington University School of Medicine and Health Sciences, discusses ...

Positron emission tomography (PET) and estrogen receptor (ER) ligand in patients with invasive breast cancer. Germline single nucleotide polymorphisms (SNPs) in XRCC3, XRCC1, and XPD, and survival ...

The JAK/STAT (Janus Kinase-Signal Transducer and Activator of Transcription) signalling pathway controls the activity of various cytokines and growth factors. The ...

John Mascarenhas, MD: So JAK inhibitors are a class of agents. They’re oral agents. There are probably at least a dozen that have been in clinical development. And what they do is potently inhibit a ...

Scientists at Children’s Hospital of Philadelphia (CHOP) say they have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease (IBD). The genetic pathway ...

Myeloproliferative neoplasms (MPNs) represent a cluster of conditions characterized by the excessive production of blood cells within the bone marrow. Among MPN patients, abnormal quantities of red ...