Like poles support a tent, microtubules—hollow cylindrical structures made of tubulin protein—support eukaryotic cells. But microtubules provide more than just mechanical strength; they help prepare ...

Like poles support a tent, microtubules - hollow cylindrical structures made of tubulin protein - support eukaryotic cells. But microtubules provide more than just mechanical strength; they help ...

Mitotic cell division, when a cell splits into two identical daughter cells, involves lots of moving parts that must be properly organized for accurate segregation. The main players responsible for ...

In eukaryotic cells, the onset of mitosis involves cyclin molecules which interact with proteins of the cdc2 family to produce active kinases. In vertebrate cells, cyclin A dependent kinases become ...

Direct evidence that microtubules function as mechano-sensors and regulate the intracellular transport of molecules has been reported, leading to new possibilities in the fields of biomechanics, ...

As organisms grow, live, and move through the world, they're subjected to an array of internal and external forces. Biological forms must be able to withstand the stresses of stretching and ...

Eukaryotic cilia and flagella are essential organelles that extend from the cell surface, playing crucial roles in sensory ...

Proteins containing disordered domains perform many important cellular functions. My lab currently has two main projects, one to dissect the role of tubulin's C-terminal tail in microtubule structure ...

The microtubule-associated protein (MAP) Tau is an intrinsically disordered protein (IDP) primarily expressed in axons, where it functions to regulate microtubule dynamics, modulate motor protein ...

Direct evidence that microtubules function as mechano-sensors and regulate the intracellular transport of molecules has been reported, leading to new possibilities in the fields of biomechanics, ...