On the Eagles' end, their weakness has been turnovers. Philadelphia has four games this year with two or more turnovers and the Eagles have gone 0-4 in those games. If any defense out there can take advantage of that, it's a Bills unit that has forced 20 turnovers this year, which ranks in the top eight in the NFL.

Will the Chicago Bears defeat the San Francisco 49ers in prime time? We make our Week 17 picks and predictions.

Each pick has a confidence level of 1-10, with 10 being the most confident. For more information on the pick methodology, check out the Week 1 edition of this series. Keep in mind that since the idea here is to make high-percentage plays,

SportsLine's proven computer model has identified it's top NFL picks for Week 17 divisional rivalry matchups at DraftKings

With Jess losing with his pick of the Indianapolis Colts to cover the 6.5 points last Monday night against the San Francisco 49ers and the Pittsburgh Steelers delivering a direct hit with their outright victory over the Detroit Lions, that increased my record to 7-8-1 and dropped Jess to 5-11.

Week 17 is also loaded with playoff implications. Teams like the Houston Texans (10-5), Los Angeles Chargers (11-4), Chicago Bears (11-4) and San Francisco 49ers (11-4) are still vying for higher seeds in the AFC and NFC.