Negative feedback is a universal control mechanism that lets a system's output throttle its input. If an engine revs up, negative feedback tapers its power source. But if the engine slows down, it ...

The tumour suppressor p53 transactivates the expression of its target genes to exert its functions. Here, we identify a pleckstrin homology domain-containing protein (PHLDB3)-encoding gene as a p53 ...

This is a preview. Log in through your library . Journal Information PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, ...

In football, defense keeps the opposing team in check. A similar strategy is at play inside our cells. Negative feedback loops (NFLs) help regulate how cells respond to signals, for example, dialing ...

“The only way to discover the limits of the possible is to go beyond them into the impossible.” – Arthur C. Clarke Even worse: some of these laws go back decades with little to no effort to improve ...

The function of a protein can depend on its abundance in a cell. So, when investigating the properties of a new protein, it is essential to make sure that the same amount is produced by every cell.