Endothelial-to-Osteoblast Conversion (EC-to-OSB) regulates bone formation and homeostasis via the Kindlin-2/Piezo1/TGFβ/Runx2 axis. Reduced Kindlin-2 in endothelial ...
A research team has discovered a new mechanism and drug combination strategy that can effectively treat osteoporosis, a ...
Osteoblasts act in a group to make bone over the course of several months. However, how osteoblasts cooperate with each other in vivo is still unknown. Now, researchers at Osaka University established ...
Wif1 overexpression accelerated osteogenic differentiation by activating genes related to late-stage osteogenic differentiation and mitophagy processes. Moreover administering Wif1-overexpressing ...
Epigenetic alterations in peripheral blood cell DNA and implications for breast cancer detection, prognosis, and treatment. Background: Bisphosphonates (BPs) are widely used for the treatment in bone ...
Stem cells and progenitor cells reside in various tissues of the body and are capable of generating daughter cells of different lineages. Mesenchymal stem cells (MSCs) are multipotent stromal cells ...
New research uncovers how the Clec14a protein in capillary endothelial cells controls bone growth and maturation, revealing a key mechanism in skeletal development. Study: Type-H endothelial cell ...