Michael S. Fernandopulle is in the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda 20892, Maryland USA. Michael E. Ward is in the National Institute of ...

A single human cell teems with as many 100,000 different proteins. Actin is one of the most abundant and essential of them all. This protein forms into filaments that help make up the skeleton of ...

Understanding how microscopic interactions between proteins in cells produce large-scale organization and asymmetry is a fundamental question in cell biology.

The cryogenic electron microscope structure of the A4p-activated (green) CalpL protein filament (violet) from Candidatus Cloacimonas acidaminovorans (PDB ID: 9EYJ). CRISPR-Cas systems help to protect ...

(Phys.org)—The plasma membranes that give cells their shapes are typically upheld by linear meshworks of the protein actin. In contrast, Howard Hughes Medical Institute scientists have now discovered ...

Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an estrogen independent manner. Targeting vimentin and/or the long ...

These newly designed protein components snap together spontaneously into filaments. The designed proteins are relatively small, made up of about only 180 to 200 amino acids and measure only about on ...

Many neurodegenerative diseases, including Alzheimer's, are characterized by tangled proteins called Tau fibrils. In a new study, MIT chemists have gained insight into how these fibrils form and ...

Protein molecules require a defined shape in order to function. When they are created, their building blocks are therefore linked together in a very specific way. Researchers are now taking a closer ...

Biophysicists have gained a new insight about the dynamics of cellular movement, which is key to processes ranging from stem-cell differentiation and wound healing to the development of diseases such ...