Python hunter Bayo Hernandez prefers his snake ground up like hamburger meat with ketchup, mustard, and mayo. Another hunter fancies the slithering scourge of the Everglades in a stir fry or chili.

Pythons, the long, slithering reptiles that can grow up to 33 feet—about the length of a bus—are usually known for their role in the animal kingdom and the fashion industry. But have you ever ...