Cyclic induction of the Yamanaka reprogramming factors for four weeks before stroke reduced ischemic brain damage, preserved ...

Pancreatic cancer is one of the most aggressive and difficult-to-treat cancers. One reason for its resistance to therapy is ...

A seven-cohort single-cell atlas links early-onset colorectal cancer to coordinated epithelial, stromal and NOTCH-associated ...

Human cells hold about two meters (6.6 feet) of DNA, folded and compacted to fit inside a nucleus. That packing is essential ...

Researchers reprogrammed an 80-year-old's blood cells to an epigenetic age below 20, creating a lab model for studying ...

The first humans are trying out cellular reprogramming for longevity. It looks like it might be working.

Cellular reprogramming enables scientists to reset the biological clock of mature human cells without stripping away their ...

A single dose of ORK1 generated durable disease control in two independent inflammatory bowel disease mouse models ORK1 induced sustained myeloid ...

Every organ and tissue progressively loses function and integrity as it ages. In fact, researchers have identified "hallmarks ...

Metabolic reprogramming is a defining hallmark of CRC. The Warburg effect is the principal metabolic feature of CRC cells, wherein glucose is preferentially catabolized into lactate to sustain ...

Direct reprogramming of human blood cell precursors into neural stem cells gradually reversed molecular signs of aging.

Researchers have identified key factors that promote the reprogramming of human stem cells to the naïve state, which can be used to model the earliest stages of development. This new knowledge will ...