TDP-43 self-assembles into oligomers that are able to recruit Aβ to form oligomers of its own, claims a paper in the September 12 Nature Communications. Using a new TDP-43 oligomer antibody, the ...

Scientists are revealing mroe about why TDP-43 has long been linked to the neurodegenerative disorders Alzheimer's, FTD, and ...

Neuronal TDP-43 pathology marks most cases of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but how does a single protein fit with such a wide range of symptoms? Researchers ...

Niigata, Japan - Amyotrophic lateral sclerosis (ALS) is an intractable neurological disease. Aging is a risk factor for the accumulation of TDP-43 (transduction responsive region DNA-binding protein ...

A team of researchers has developed a laboratory model that recapitulates the pathological aggregation of TAR DNA-binding protein 43 (TDP-43), a hallmark of amyotrophic lateral sclerosis (ALS) and ...

International research team including the Korea Brain Research Institute found Cryptic Exons by cell types. Early diagnosis of degenerative brain nervous system disease and development of therapeutic ...

New research led by the Cold Spring Harbor Laboratory Associate Professor Molly Gale Hammell could pave the way for improved diagnosis and more effective treatments for amyotrophic lateral sclerosis ...

The TDP-43 RNA-binding protein is found in abnormal cytoplasmic inclusions in affected motor neurons in almost all ALS cases, and mutations in the TDP-43 gene (TARDBP) cause a rare form of familial ...

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, researchers report 'seeding' this accumulation through fragments of the culprit ...