WASHINGTON (AP) — After a weekend of setbacks, the Senate will try to sprint ahead Monday on President Donald Trump’s big bill of tax breaks and spending cuts despite a series of challenges, including the sudden announcement from one GOP senator that he won’t run for reelection after opposing the package over its Medicaid health care cuts.

Republican senators sifted through familiar procedural hurdles toward a final vote on legislation that would dramatically transform the tax code and Medicaid.