A single genetic test could potentially replace the current two-step approach to diagnosing rare developmental disorders in children. This shift could enable earlier diagnoses for families and save ...
A surprising amount of the DNA sequence in the genes of humans and other higher organisms ends up on the cutting-room floor, so to speak, spliced out by the cellular machinery that turns genetic code ...
Since their inception in 1995, DNA microarrays have become the icon of the genomics revolution. Everyone with any interest has become familiar with the images of precise rows and columns of colored ...
Though DNA microarrays let researchers rapidly identify the expression levels of genes associated with diseases and pathways, they say little about how much protein these transcripts produce. A new ...
In the years since they were first developed, microarrays have been applied to an extraordinary range of situations. But in 2001, some researchers began to voice concerns that the increasingly ...
JA Rosenfeld is an employee of Signature Genomic Laboratories, a subsidiary of PerkinElmer, Inc. The authors have no other relevant affiliations or financial involvement with any organization or ...
A single genetic test could potentially replace the current two-step approach to diagnosing rare developmental disorders in children. This shift could enable earlier diagnoses for families and save ...
Phase II Clinical Trial of a Granulocyte-Macrophage Colony-Stimulating Factor–Encoding, Second-Generation Oncolytic Herpesvirus in Patients With Unresectable Metastatic Melanoma As a result of the ...
Genetic aberrations that cause a gain or loss of chromosomal material are associated with mental retardation and congenital malformations and linked to development of cancer. Comparative genomic ...
Despite the known risk factors for CR, it is not possible to predict which patients will develop CR and at what time point after transplant. Given the significant morbidity and mortality associated ...
As difficult as it was to sequence the 3.1 billion chemical “letters” that make up human DNA, the harder task may be to figure out what they mean. Trying to determine what’s going on in a particular ...
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