How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But ...

Messenger RNAs (mRNAs) possess unique properties making them great therapeutic candidates. However, delivering mRNA drugs to target cells is challenging. Protein nanocages (PNCs) are nanostructures ...

Caltech scientists have developed a new type of vaccine that works like a hybrid of mRNA and protein nanoparticles. In tests in mice, the prototype produced five times more antibodies than existing ...

Nucleic acid-based therapeutics, including antisense oligonucleotides (ASO), small interfering RNA (siRNA), messenger RNA (mRNA), immunomodulatory DNA/RNA, and gene-editing guide RNA (gRNA), hold ...

In the fast-evolving field of medical science, a new artificial intelligence model may be about to change the way mRNA-based drugs and vaccines are designed. Developed through a collaboration between ...

RNA vaccines, such as those used against COVID-19, are effective at generating antibody responses. These antibodies are produced through specialized immune structures called germinal centers, but ...

Imagine a cancer treatment that precisely targets malignant cells, leaving healthy ones untouched. Consider, also, a cancer treatment that corrects abnormal protein synthesis to produce healthy ...

Maintenance of mRNA and protein localization in motor neurons is a potential therapeutic avenue for Amyotrophic lateral sclerosis (ALS), report researchers from The Francis Crick Institute and the ...

Myocarditis that arises after receipt of an mRNA-based COVID-19 vaccine among adolescents and young adults does not appear to result from a heightened overall immune response or from autoantibodies, ...

Imagine a breakthrough in cancer treatment where only malignant cells are targeted, sparing healthy host cells; or patients with abnormal protein synthesis are treated to produce a healthy protein.