A 36-year-old woman presented with acute-onset abdominal pain and subacute constitutional symptoms. Subdiaphragmatic free air was seen on imaging, and she was taken to the operating room, where ile ...

In vitro fertilization is clearly a successful technology, although it remains experimental; the safety and efficacy of new methods and reagents can be difficult to assess. And “traditional ...

The author describes pronuclear transfer, a type of mitochondrial donation, which was made available to women with mitochondrial DNA disease in a reproductive care pathway implemented in Newcastle, ...

After a year of clinical rotations in which a medical student learns to face death up close, her experience on a silent meditation retreat provides her with new perspective on death and life.

Sarcoidosis, a granulomatous disease that affects the lungs and other organs, has a variable course. Although spontaneous resolution of sarcoidosis occurs in some patients, half the patients with s ...

Leading cardiologists discuss PARADIGM-HF, a trial of angiotensinneprilysin inhibition versus enalapril in advanced heart failure.

The discovery of a highly efficacious option for preexposure prophylaxis that requires only twice-yearly administration has led to the question of whether a vaccine is still needed to end the HIV ...

A 55-year-old woman started treatment with meropenem and minocycline for a polymicrobial infection. Within 1 week, she had tongue discoloration that was consistent with black hairy tongue.

Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying pathog ...

Real-world data could help advance disease prevention and treatment, enhance quality of care, and empower patients to improve their health. But various challenges continue to impede their utilization.

To the Editor: In the API-CAT trial (April 10 issue),1 Mahé and colleagues confirm that a reduced dose of apixaban (2.5 mg twice daily) is noninferior to a full dose (5.0 mg) of the drug for ...

The authors describe the implications of the Affordable Care Act for safety-net health systems and how hospital-based safety-net care systems are responding to health care reform.