Zon envisions using these approaches to treat clonal hematopoiesis. In this precancerous condition, which becomes more common ...

A recent study in zebrafish presents a potentially important new system for studying the process of stem cell biology and hematopoiesis, the process by which blood is produced. The zebrafish has ...

Heart muscle cells grown from stem cells show promise in monkeys with a heart problem that typically results from a heart ...

This subjects the donor cells to a fair amount of replicative stress. Some scientists are concerned that this stress could lead to clonal hematopoiesis, a phenomenon where the donated stem cells ...

Skeletal stem cells have been isolated from various tissues, including periosteum and bone marrow, where they exhibit key functions in bone biology and hematopoiesis, respectively. The role of ...

While responses to inflammation may be necessary to maintain normal and emergency hematopoiesis, it may be deleterious over the long term, with prolonged inflammation leading to stem cell exhaustion ...

In particular, the lab is investigating the role of DNA methyltransferase 3a (DNMT3A) in regulating stem cell function, and how mutations in DNMT3A lead to age-related clonal hematopoiesis and ...

Single-cell analysis of CML patients bone marrow at diagnosis reveals coexistence of CD26-CD35+ healthy stem cells and CD26+CD35- CML stem cells, and how the ratio between these impacts TKI response.

The condition, called clonal hematopoiesis of indeterminate potential (CHIP), develops when some hematopoietic stem cells, ...

enabling answers to long standing questions in stem cell research with a focus on hematopoiesis, pluripotent stem cells and their differentiation and bone biology. His work combines cell and molecular ...