49ers head coach Kyle Shanahan told reporters Monday that McCaffrey suffered a posterior cruciate ligament (PCL) injury during Sunday's 35-10 loss to the Buffalo Bills, and will be placed on injured reserve as result. McCaffrey's recovery is expected to be six weeks, meaning that the rest of his season is in jeopardy.

The San Francisco 49ers running back injured the PCL in his knee, an MRI confirmed Monday. San Francisco plans to place McCaffrey on injured reserve. He is expected to miss six weeks. Head coach Kyle Shanahan announced the news during his Monday press conference.

Christian McCaffrey ’s challenging 2024 NFL season took a devastating turn on Sunday when the San Francisco 49ers ’ star running back sustained a potential season-ending injury in a 35-10 loss to the Buffalo Bills.