Republican Senator Lindsey Graham of South Carolina has called for a regime change in Iran, saying President Donald Trump should go "all in" to help Israel combat Iran's nuclear threat. Israel on Friday launched attacks against Iran's capital city of Tehran in what it called a "preemptive strike" and warned its citizens of retaliatory bombings from Iran.

Sen. Lindsey Graham, R-S.C., discusses how President Donald Trump is handling conflicts in the Middle East on ‘Hannity.’

Sen. Lindsey Graham told CBS's "Face The Nation" that he urges President Trump to be prepared to join Israel's attack on Iran up to and including "regime change," if a single American is targeted by Iran.