In the case of biofilms, the nature of the extracellular matrix makes SERS methods particularly challenging since it is chemically complex, contains multiple constituents known to interact strongly ...

Step 4: p-cMGP is secreted into the extracellular matrix or the circulation to inhibit soft tissue calcification, VSMC (vascular smooth muscle cell) trans-differentiation into OPC (osteochondrogenic ...

The study presents a potentially valuable approach to genetically modify cells to produce extracellular matrices ... cellular morphology, matrix staining, surface regularity, cartilage thickness, ...

Cells can sense when the extracellular matrix has been exposed to matrix metalloproteinases (MMPs), even if the exposure is slight and does not alter matrix stiffness. We show that cells sense ...

Allografts, synthetic bone grafts, and demineralized bone matrix are the most commonly used bone grafts worldwide. In addition, increase in cases of lifestyle disorders such as diabetes and obesity ...

Osteosarcoma (OS) is the most common malignant bone cancer. Thirty to forty percent of all patients with OS develop tumor recurrence, almost exclusively in the form of lung metastasis, which is ...

Kindlin-2 loss accelerates hepatocyte apoptosis with subsequent compensatory cell proliferation and accumulation of the collagenous extracellular matrix, leading to massive liver fibrosis and ...

Cells and extracellular matrix (ECM) components represent the multifaceted and dynamic environment that distinguishes each organ. Cancer is characterized by the dysregulation of the composition and ...

They span beyond the collagen-related pathways to include signaling cascades regulating bone cell function and the extracellular matrix, as described in detail below. The great variability in clinical ...