France host Wales on Friday night in the opening game of the 2025 Six Nations seeking a first title in the tournament since rampaging past all contenders for the 2022 crown.

It all kicks off on Friday night in Paris where France are looking to begin a fresh title challenge at home to Wales who seem destined for a wooden spoon battle. Scotland host Italy and, like the French, need a statement victory to kick things off if they are going to present themselves as credible candidates to win the whole thing.

Wales are similar odds to beat France in Paris as Japan were when they famously downed South Africa 34-32 at the 2015 Rugby World Cup. That was the biggest upset in World Cup history, and a Wales win tonight would be one of the biggest in Six Nations history.