Skeletal stem cells have been isolated from various tissues, including periosteum and bone marrow, where they exhibit key functions in bone biology and hematopoiesis, respectively. The role of ...

This subjects the donor cells to a fair amount of replicative stress. Some scientists are concerned that this stress could lead to clonal hematopoiesis, a phenomenon where the donated stem cells ...

Hematopoiesis recovers significantly before 5 months ... They find that periosteum skeletal stem cells (p-SSCs) are the primary source of BM-MSCs within the grafted femur and that these cells are more ...

Here, we show that hematopoiesis in the mice with Wbp1l germline deletion is dysregulated, already at the level of hematopoietic stem cells and early progenitors. We further demonstrate that thymi of ...

New drugs and therapies have become indispensable for treating an array of cancers. Unfortunately, they can also cause damage to the heart, a side effect that has led to the development of a new ...

Initial Results from the BEACON Clinical Study: A Phase 1/2 Study Evaluating the Safety and Efficacy of a Single Dose of ...

In alignment with Jasper's clinical development plan, Jasper obtained regulatory clearance to enroll a 180mg dose cohort ...

P1, the registration-directed study of luveltamab tazevibulin for pediatric patients with CBFA2T3::GLIS2 acute myeloid leukemia, has been initiated and is open for enrollment. In December 2023, Dr.

REFRaME-P1 is a registration-enabling study evaluating the efficacy and safety of luvelta in infants and children under 12 years of age with CBF/GLIS AML. This will be a global study, with the ...

Long term survival rates are poor due to transfusion burden and its associated morbidities, as well as a lack of curative ...