Search and compare Sioux Falls, SD hotels and accomomodations using our interactive hotel finder. Explore by amentities, price, map, and rating and let us help you choose the best hotel in Sioux ...

SIOUX FALLS, S.D., May 13, 2025 /PRNewswire/ -- Home2 Suites Sioux Falls Sanford Medical Center unveiled a new look following a recent renovation. The hotel, connected to Sanford Medical Center in ...