A clinical trial involves the study of the safety, efficacy and/or dosage regimen of a therapeutic intervention (such as a drug) in humans selected according to predetermined criteria of ...

This Review provides an update on the role of innate and adaptive immune cells in the pathogenesis of osteoarthritis. The authors discuss emerging therapeutics that target the immune system in ...

In this Journal Club, Minoli Perera reflects on a 2005 sequencing study by Cohen et al., who discovered two common loss-of-function mutations with large effects on plasma cholesterol levels thanks ...

Cheng et al. identify a mitochondrial complex IV (CIV) deficiency in the brains of patients with sporadic amyotrophic lateral sclerosis (ALS). They demonstrate that defects in mitochondrial CIV ...

Inflammation is a biological response to harmful stimuli, such as pathogens, damaged cells or irradiation. It is a protective attempt by the organism to remove injurious stimuli and to initiate ...

Simon Schlehuber and colleagues model autonomous hydrogen-powered boats as a sustainable transport solution and find potential cost benefits over longer distances. This research could inform ...

Antibiotic treatment usually selects for fast-growing bacterial cells, but that is not always the case. Here, Kim et al. show that antibiotic-induced changes in bacterial communities depend on ...

Digital image correlation measurements show that nominally stationary interfaces subjected to constant shear and normal loads are sliding at extremely small rates, confirming the predictions of ...

Environmental science is the multidisciplinary study of all aspects of the Earth’s physical and biological environments. It encompasses environmental chemistry, soil science, ecology ...

Archaeology is the study of the artefacts and other physical evidence left by past societies of humans and closely related species. It uses scientific analysis of field samples to inform ...

Panzer and colleagues show that the integrated stress response pathway regulates cytokine translation in CD4 + T RM cells during homeostasis and inflammation. New immunotherapies have the ...

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