The mechanism of aspirin action includes both central and peripheral mechanisms. The primary mechanism of action is to block the production of prostaglandins in injured peripheral tissues, which ...

It is possible that therapeutic ASA regimes directed toward inhibition of platelet function, as evaluated in vitro in platelet-rich plasma, might not reflect therapeutic efficacy in vivo due to the ...

Inclusion criteria: Adults (18 years old or older) taking antiplatelet drugs for at least 2 weeks; scheduled for elective or emergency neurosurgery under general anaesthesia (craniotomy, spinal cord ...

Water therapy, knee braces, and exercise are more effective than high-tech treatments like ultrasound therapy for knee ...

Mpalantinos et al. (1998) suggest that the substances that promote this therapeutic action are the flavonoids and kavalactones obtained from the aqueous extract of A. zerumbet. Concomitant with these ...

Aspirin The mode of action of aspirin as an antiplatelet agent is through an irreversible acetylation of the serine 509 of the COX-1 enzyme resulting in the inhibition of thromboxane A 2 ...

The mechanism of action (MoA) of a clickable fatty acid analogue 8-(2-cyclobuten-1-yl)octanoic acid (DA-CB) has been investigated for the first time. Proteomics, metabolomics, and lipidomics were ...

Resistance and nonresponse to aspirin dramatically decreases its therapeutic efficacy. To overcome this issue, a small-molecule thrombus-targeting drug delivery system, aspirin-Arg-Gly-Asp-Val (A-RGDV ...

High-dose aspirin (HDA) is used with intravenous immunoglobulin (IVIg) in Kawasaki disease (KD). Practice regarding HDA varies, and it is unclear whether HDA duration affects the long-term course.

Action Games; Killer Inn is a new murder mystery game that sounds a lot like Among Us, but looks a lot more like a chaotic, 24-player version of Hitman. News. By Catherine Lewis published 6 June 2025 ...

Citation: Huang Y, Ma W, Guo C and Su X (2025) Mechanism of action and potential therapeutic targets of TGF-β-related signaling pathway and its downstream miRNA expression in pulmonary arterial ...