Acetaminophen (known as Paracetamol in the UK), ranks among the most widely used medications worldwide. It’s most commonly ...

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According to a new study in rats, a key byproduct of acetaminophen, called AM404, may block pain at the source before it has a chance to reach the brain.

Acetaminophen overdoses can damage the liver and are responsible for 56,000 emergency visits a year in the U.S. "Whole families of new drugs could be designed based around blocking sodium channels.

Acetaminophen (APAP), known as paracetamol, has been a common antipyretic and analgesic globally since 1884 (Brune, Renner and Tiegs, 2015). While safe at recommended doses, overdoses can lead to ...

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Acetaminophen, on the other hand, works by "inhibiting COX enzymes and modulating the endocannabinoid system in the central nervous system (brain and spinal cord) to exert its effects," Wu said.

The new discovery According to the study’s background material, acetaminophen’s active metabolite, AM404, “shuts down specific sodium channels in pain-sensing neurons” so that the pain signals don’t ...