The San Francisco 49ers may again be without starting quarterback Brock Purdy for their Week 13 clash with the San Francisco ...

The Buffalo Bills will have to wait and see what happens with tight end Dalton Kincaid as his status for this week is up in ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

The San Francisco 49ers are 5-6 entering their matchup with the Buffalo Bills on Sunday, and an NFL executive called out ...

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

Following their bye week, the Bills (9-2) will take on the San Francisco 49ers (5-6) at Highmark Stadium in Week 13. But ...

The Buffalo Bills' home-field advantage will once again be on display on Sunday night with severe weather projected to be on ...

The Buffalo Bills are heading out of the their bye and are set to face the San Francisco 49ers in Week 13 on “Sunday Night ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, ...

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...