While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

The Buffalo Bills will have to wait and see what happens with tight end Dalton Kincaid as his status for this week is up in ...

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

Following their bye week, the Bills (9-2) will take on the San Francisco 49ers (5-6) at Highmark Stadium in Week 13. But ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

The San Francisco 49ers may again be without starting quarterback Brock Purdy for their Week 13 clash with the San Francisco ...

The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air ...

There is a high Risk of Weather Impact (ROWI) for the NFL's Sunday Night Football matchup between the 49ers (5-6) and the ...

The Buffalo Bills' home-field advantage will once again be on display on Sunday night with severe weather projected to be on ...

Buffalo (9-2) will return to action on Sunday night when they host the San Francisco 49ers (5-6). The Bills are perfect ...

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...