Prostate cancer (PCa) is the second most frequently occurring cancer and the fifth leading cause of cancer mortality among men worldwide in 2022 (Bray et al, 2024). Androgen receptor (AR) is ...

Arthritis was induced in mice exposed to high blood levels of homocysteine. Hyper-homocysteinemia arthritic animals develop diastolic dysfunction (the left ventricle does not dilate properly) with ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

DNMT3A mutations may also have hitherto unrecognised non-canonical functions in HSCs. TP53 in humans, or Trp53 in mice (generally referred to as p53 throughout this text) is a key tumour suppressor ...

Neoantigen vaccine is a promising breakthrough in tumor immunotherapy. However, the application of this highly personalized strategy in the treatment of solid tumors is hindered by several obstacles, ...

The ER membrane protein SELENOT has been previously suggested to be neuroprotective, but its contribution to neuronal pathophysiology has not been thoroughly investigated. This study reports that ...

Recently, we were able to show that both SARS-CoV-2 infection and mRNA vaccination prime human monocyte-derived macrophages for potent secretion of pro-inflammatory cytokines following restimulation ...

Haploinsufficiency of the progranulin (PGRN)‐encoding gene (GRN) causes frontotemporal lobar degeneration (GRN ‐FTLD) and results in microglial hyperactivation, TREM2 activation, lysosomal dysfunction ...

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease ...

The endoplasmic reticulum (ER) of the eukaryotic cell is the major site of lipid and membrane protein synthesis, and it acts as a hub for intracellular communication. This organelle extends from the ...

Metabolic requirements of dividing hepatocytes are prerequisite for liver regeneration after injury. In contrast to transcriptional dynamics during liver repair, its metabolic dependencies remain ...

Alveolar type 2 (AT2) cells maintain lung health by acting as stem cells and producing pulmonary surfactant. AT2 dysfunction underlies many lung diseases, including interstitial lung disease (ILD), in ...