Succinate dehydrogenase (SDH) or succinate-coenzyme Q reductase (SQR) or respiratory complex II is an enzyme complex, found in many bacterial cells and in the inner mitochondrial membrane of …

Jan 31, 2003 · Eukaryotic complex II (equivalent to SQR in E. coli) directly connects the respiratory chain of the inner mitochondrial membrane with the Krebs cycle enzymes in the mitochondrial matrix. …

Complex II is another group of proteins that serves as a second entry point into the electron transport chain, which is involved in the additional production of ATP to power cellular processes.

Jun 18, 2025 · Complex II holds a unique position in cellular metabolism because it participates in two interconnected pathways: the Krebs cycle and the electron transport chain. This dual functionality …

Mitochondrial complex II is traditionally studied for its participation in two key respiratory processes: the electron transport chain and the Krebs cycle. There is now a rich body of literature explaining how …

This protein complex contains the enzyme succinate dehydrogenase, which catalyzes the conversion of succionate to fumarate in the TCA cycle and in the process energizes FAD to FADH 2. In Complex II …

Complex II does not pump protons across the inner mitochondrial membrane, which differentiates it from Complexes I, III, and IV. Mutations or deficiencies in Complex II can lead to various mitochondrial …

Complex II deficiency disrupts mitochondrial energy production, causing CNS, muscle, and heart issues, diagnosed through blood tests and muscle biopsy.

Jul 24, 2023 · Complex II catalyzes the oxidation of succinate to fumarate. The electrons produced during this reaction are transferred to the electron transport chain (ETC), where they are used to …

Complex II is the only membrane-bound component of the Krebs cycle and in addition functions as a member of the electron transport chain in mitochondria and in many bacteria.