IgG4 related disease (IgG4-RD) encompasses a constellation of individual organ disorders that share particular pathologic, serologic, and clinical features. These disorders were previously …

The disease is defined by mass forming lesions containing abundance of IgG4 producing plasma cells, lymphocytes and fibrosis, mimicking malignancy. IgG4-RD is responsive to …

IgG4-related disease (IgG4-RD), formerly known as IgG4-related systemic disease, is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4 …

Sep 8, 2025 · The clinical features, diagnosis, and differential diagnosis of IgG4-RD are presented here. The treatment and prognosis of IgG4-RD are described separately. (See "Treatment and …

Laboratory tests used in the workup for IgG4-RD include measurement of IgG4 serum level, autoantibody tests to rule out IgG4-RD mimickers, and tests to identify affected organs, in …

Supporting the diagnosis of IgG4-related disease

The diagnosis of IgG4-related disease may require a tissue biopsy of the affected organ demonstrating the aforementioned histological features. It is recommended that patients …

Aug 2, 2025 · This test checks the amount of certain antibodies called immunoglobulins in your body. Antibodies are proteins that your immune cells make to fight off bacteria, viruses, and …

An increased number of IgG4+ plasma cells detected by this antibody can help establish the diagnosis, with cases showing histologic features of cutaneous pseudolymphomas and/or intra …

IgG4 test results are typically reported as either “normal” or “abnormal.” Most people will have a normal result from this blood test. When there is an abnormal result due to high levels of IgG4, …