The β 2 microglobulin consists of a single non-polymorphic molecule noncovalently bound to the alpha chain and is encoded on chromosome 15 (Figure 2 and Figure 3).

Schematic representation of MHC class I β 2 microglobulin lies beside the α 3 chain on the cell surface. Unlike α 3, β 2 has no transmembrane region. Directly above β 2 (that is, further away …

Jul 26, 2025 · These antigens are displayed in a groove formed by the alpha chain and beta-2 microglobulin, making them visible to T-cells. When a cell is infected with a virus or becomes …

They consist of a heavy chain (alpha chain) encoded by the HLA-A, -B, or -C genes and a small protein called beta-2 micro globulin. The heavy chain has three extracellular domains: alpha-1, …

May 23, 2022 · It contains the binding site for the T-cell accessory molecule CD8. The transmembrane and the cytoplasmic domains ensure that the alpha chain spans the …

MHC class II complexes consists of α-and β-chains that are assembled in the ER and are stabilised by invariant chain (Ii). The complex of MHC class II and Ii is transported through the …

Jul 7, 2025 · Found on almost all nucleated cells, Class I molecules are composed of a heavy $\alpha$ chain (45 kD) and a light chain called $\beta$2-microglobulin (12 kD). The $\beta$2m …

Nov 13, 2025 · Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long …

To respond to an antigen, the first criterion that must be met is that the individual must have an MHC molecule that can bind and present the antigen. The second criterion that must be met is …

Jul 15, 1994 · Normally, Ag is presented to CD8 + T lymphocytes as a tripartite complex consisting of peptide epitope, MHC-encoded class I heavy (alpha) chain, and beta 2 …