Targeting p53 pathways: mechanisms, structures and advances ...
Mar 1, 2023 · In this review, we aim to provide a comprehensive summary of the biological function of p53, p53 signaling pathway, the structural features of p53 protein, as well as the …
Tumor Suppressor p53: Biology, Signaling Pathways, and ...
This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response …
p53 - Wikipedia
p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is …
p53 Pathway for Apoptosis Signaling - Thermo Fisher Scientific
What is the p53 pathway and how does p53 induce apoptosis? The p53 mediated apoptosis pathway is one of the major apoptosis signaling pathways involving the stimulation of both the …
p53 Pathway - Addgene
p53 is a transcription factor and tumor suppressor activated by cellular stresses like DNA damage, oxidative stress, and nutrient deprivation. p53 is activated through both phosphorylation and …
p53 Signaling Pathway: Insights and Regulatory Mechanisms
Apr 29, 2025 · Explore the p53 signaling pathway, its regulatory mechanisms, and its role in maintaining cellular integrity and response to stress.
Targeting the p53 signaling pathway in cancers: Molecular ...
Despite the difficulties, targeting the p53 pathway remains a top priority in cancer research. Therefore, we systematically classified the important or new gene targets in the p53 pathway …