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Karthikeyan Pethusamy
Mechanism of Action of Acyclovir
Acyclovir is an antiviral drug used mainly for herpes zoster infection. Acyclovir is selectively acted upon by the viral thymidine kinase. The enzyme phosphorylates acyclovir to a monophosphate. The acyclovir monophosphate (acyclo-GMP) is subsequently converted to acyclovir triphosphate (acyclo- GTP) by human enzymes. Acyclo-GTP persists is a ...
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