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Life Cycle of Red Blood Cells Production Red blood cells (RBCs) are produced through erythropoiesis in the bone marrow over 7 days, stimulated by erythropoietin (EPO) from the kidneys. Reticulocytes, the developing cells, comprise about 1% of circulating RBCs. Lifespan RBCs circulate for 100-120 days (80-90 days in infants). They are moved by blood flow and recycled in the bone marrow. Senescence Aging RBCs are recognized and phagocytosed by macrophages, including Kupffer cells in the liver. Thi
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